QUANTITATIVE COMPARISON OF DIETARY FIBRES FOR VITAMIN B12 ENCAPSULATION
Keywords:
Vitamin B12, encapsulation, dietary fibre matrices
Abstract
Vitamin B12, also referred to as Cobalamin, is an essential nutrient for the human body. DNA synthesis, neurological functions, and haematopoiesis are a few of the vital roles vitamin B12 plays. However, it is concerning that a significant 47% of the Indian population is grappling with a deficiency in this vital nutrient. Vitamin B12 supplements in the form of capsules and tablets serve to solve this problem. We hereby explore a solution which is not only efficient but also sustainable, namely, Vitamin B12 encapsulation in environmentally friendly matrices via ionotropic gelation. Dietary fibres have been explored especially well in the food industry as encapsulating matrices and are known to have the potential for controlled release of bio actives in the pharmaceutical industry. This research work provides a comparison of the concentrations of different dietary fibres, namely alginate, pectin and cellulose required to encapsulate Vitamin B12. It serves as a starting point to discovering the full potential of these capsules in helping to solve the pressing issue of vitamin B12 deficiency.
References
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16)Ward, M., Kariyawasam, V. C., Mogan, S. B., Patel, K., Pantelidou, M., Sobczyńska‐Malefora, A., Porté, F., Griffin, N., Anderson, S., Sanderson, J., Harrington, D. J., & Irving, P. (2015). Prevalence and Risk Factors for Functional Vitamin B12 Deficiency in Patients with Crohnʼs Disease. Inflammatory Bowel Diseases, 21(12), 2839–2847. https://doi.org/10.1097/mib.0000000000000559
17) Cyran, E. M. (2002). Vitamin B12 deficiency: Recognition and Management. Primary Care Case Reviews, 5(2), 53–60. https://doi.org/10.1097/00129300-200206000-00001
18)Lee, Kuen Yong, Mooney, David J(2012), Progress in polymer science 37(1) 106-126 https://doi.org/10.1016/j.progpolymsci.2011.06.003
19)Richards, Heidi Lynn, Baker, Priscilla G. L., Iwuoha, Emmanuel,(2012), Metal Nanoparticle Modified Polysulfone Membranes for Use in Wastewater Treatment: A Critical Review, 02(03) 183-1933 https://doi.org/10.3390/molecules23040942
20)Smrdel, P., Bogataj, M., & Mrhar, A. (2008). The influence of selected parameters on the size and shape of alginate beads prepared by ionotropic gelation. Scientia Pharmaceutica, 76(1), 77–89. https://doi.org/10.3797/scipharm.0611-07
21)Aguilar, K. C., Tello, F., Bierhalz, A. C. K., Romo, M. P., Martínez-Flores, H. E., & Grosso, C. R. F. (2015). Protein adsorption onto alginate-pectin microparticles and films produced by ionic gelation. Journal of Food Engineering, 154, 17–24. https://doi.org/10.1016/j.jfoodeng.2014.12.020
22)Smyth, M., M’Bengue, M., Terrien, M., Picart, C., Bras, J., & Foster, E. J. (2018). The effect of hydration on the material and mechanical properties of cellulose nanocrystal-alginate composites. Carbohydrate Polymers, 179, 186–195. https://doi.org/10.1016/j.carbpol.2017.09.002
23)Shen, B., Guo, Z., Huang, B., Zhang, G., Peng, F., & Hu, S. (2022). Preparation of hydrogels based on pectin with different esterification degrees and evaluation of their structure and adsorption properties. International Journal of Biological Macromolecules, 202, 397–406. https://doi.org/10.1016/j.ijbiomac.2021.12.160
2)Singla, R., Garg, A., Surana, V., Aggarwal, S., Gupta, G., & Singla, S. (2019). Vitamin B12 Deficiency is Endemic in Indian Population: A Perspective from North India. Indian Journal of Endocrinology and Metabolism, 23(2), 211–214. https://doi.org/10.4103/ijem.IJEM_122_19
3)Smith, A. D., Warren, M. J., & Refsum, H. (2018). Chapter Six—Vitamin B12. In N. A. M. Eskin (Ed.), Advances in Food and Nutrition Research (Vol. 83, pp. 215–279). Academic Press. https://doi.org/10.1016/bs.afnr.2017.11.005
4)National Institutes of Health, Office of Dietary Supplements. (n.d.). Vitamin B12. Retrieved January 14, 2024, from https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/
5)Lee, Kuen Yong, Mooney, David J(2012). Alginate: properties and biomedical applications.(Vol. 37, 106-126)
6)Lara-Espinoza, Claudia, Carvajal-Millán, Elizabeth, Balandrán-Quintana, René, López-Franco, Yolanda, Rascón-Chu, Agustín.(2018), Pectin and Pectin-Based Composite Materials: Beyond Food Texture.(Vol. 23, Issue 4)
7)Khatun, Bably, Das, Jonali, Rizwana, Shagufta, Maji, T.K.(2023), Biodegradable polymers- a greener approach for food packaging(Green Sustainable Process for Chemical and Environmental Engineering and Science, 317-369)
8)Madene, A., Jacquot, M., Scher, J., & Desobry, S. (2005). Flavour encapsulation and controlled release – a review. International Journal of Food Science & Technology, 41(1), 1–21. https://doi.org/10.1111/j.1365-2621.2005.00980.x
9)Varankovich, N., Khan, N. H., Nickerson, M. T., Kalmokoff, M., & Korber, D. R. (2015). Evaluation of pea protein–polysaccharide matrices for encapsulation of acid-sensitive bacteria. Food Research International, 70, 118–124. https://doi.org/10.1016/j.foodres.2015.01.028
10)Gadziński, P., Froelich, A., Jadach, B., Wojtyłko, M., Tatarek, A., Białek, A., Krysztofiak, J., Gackowski, M., Otto, F., & Osmałek, T. (2022). Ionotropic gelation and chemical crosslinking as methods for fabrication of Modified-Release GELLAn Gum-Based drug delivery systems. Pharmaceutics, 15(1), 108. https://doi.org/10.3390/pharmaceutics15010108
11)Green, R., Allen, L. H., Bjørke‐Monsen, A. L., Brito, A., Guéant, J. L., Miller, J. W., Molloy, A. M., Nexø, E., Stabler, S. P., Toh, B. H., Ueland, P. M., & Yajnik, C. S. (2017d). Vitamin B12 deficiency. Nature Reviews Disease Primers, 3(1). https://doi.org/10.1038/nrdp.2017.40
12) Weissbach, H., & Taylor, R. T. (1969c). Metabolic role of vitamin B12. In Vitamins and hormones (pp. 395–412). https://doi.org/10.1016/s0083-6729(08)60763-3
13)Ling, C. T., & Chow, B. F. (1954). THE INFLUENCE OF VITAMIN B12 ON CARBOHYDRATE AND LIPIDE METABOLISM. Journal of Biological Chemistry, 206(2), 797–805. https://doi.org/10.1016/s0021-9258(19)50851-1
14)Stabler, S. P. (2013). Vitamin B12Deficiency. N Engl J Med 2013; 368:149-160, 368(2), 149–160. https://doi.org/10.1056/nejmcp1113996
15)Pawlak, R., Parrott, J. S., Raj, S., Cullum-Dugan, D., & Lucus, D. (2013). How prevalent is vitamin B12deficiency among vegetarians? Nutrition Reviews, 71(2), 110–117. https://doi.org/10.1111/nure.12001
16)Ward, M., Kariyawasam, V. C., Mogan, S. B., Patel, K., Pantelidou, M., Sobczyńska‐Malefora, A., Porté, F., Griffin, N., Anderson, S., Sanderson, J., Harrington, D. J., & Irving, P. (2015). Prevalence and Risk Factors for Functional Vitamin B12 Deficiency in Patients with Crohnʼs Disease. Inflammatory Bowel Diseases, 21(12), 2839–2847. https://doi.org/10.1097/mib.0000000000000559
17) Cyran, E. M. (2002). Vitamin B12 deficiency: Recognition and Management. Primary Care Case Reviews, 5(2), 53–60. https://doi.org/10.1097/00129300-200206000-00001
18)Lee, Kuen Yong, Mooney, David J(2012), Progress in polymer science 37(1) 106-126 https://doi.org/10.1016/j.progpolymsci.2011.06.003
19)Richards, Heidi Lynn, Baker, Priscilla G. L., Iwuoha, Emmanuel,(2012), Metal Nanoparticle Modified Polysulfone Membranes for Use in Wastewater Treatment: A Critical Review, 02(03) 183-1933 https://doi.org/10.3390/molecules23040942
20)Smrdel, P., Bogataj, M., & Mrhar, A. (2008). The influence of selected parameters on the size and shape of alginate beads prepared by ionotropic gelation. Scientia Pharmaceutica, 76(1), 77–89. https://doi.org/10.3797/scipharm.0611-07
21)Aguilar, K. C., Tello, F., Bierhalz, A. C. K., Romo, M. P., Martínez-Flores, H. E., & Grosso, C. R. F. (2015). Protein adsorption onto alginate-pectin microparticles and films produced by ionic gelation. Journal of Food Engineering, 154, 17–24. https://doi.org/10.1016/j.jfoodeng.2014.12.020
22)Smyth, M., M’Bengue, M., Terrien, M., Picart, C., Bras, J., & Foster, E. J. (2018). The effect of hydration on the material and mechanical properties of cellulose nanocrystal-alginate composites. Carbohydrate Polymers, 179, 186–195. https://doi.org/10.1016/j.carbpol.2017.09.002
23)Shen, B., Guo, Z., Huang, B., Zhang, G., Peng, F., & Hu, S. (2022). Preparation of hydrogels based on pectin with different esterification degrees and evaluation of their structure and adsorption properties. International Journal of Biological Macromolecules, 202, 397–406. https://doi.org/10.1016/j.ijbiomac.2021.12.160
Published
2024-07-30
How to Cite
[1]
RISHIKESH URS, A., DANDA, M., RAJESH BHARGAV, P., SHANBHOG, S., KUMAR, G.V., ASHOK KUMAR, H.G., MANOKARAN, S. and BODHIREDDY, T. 2024. QUANTITATIVE COMPARISON OF DIETARY FIBRES FOR VITAMIN B12 ENCAPSULATION. IIChE-CHEMCON. (Jul. 2024). DOI:https://doi.org/10.36375/prepare_u.iiche.a390.
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